Asenapine augmentation in bipolar disorders: a case series
نویسندگان
چکیده
Asenapine, a novel second-generation antipsychotic is effective in acute treatment of bipolar I disorder patients in combination with mood stabilizers even in resistant cases. Although there is no evidence for asenapine's efficacy to be superior to currently available agents, asenapine's favorable weight and metabolic profile are of clinical interest.
منابع مشابه
Risk and efficacy in cognitive functions in Bipolar Disorder II with atypical antipsychotic augmentation.
BD-II has been consistently associated with cognitive dysfunction across a broad range of cognitive domains. Atypical antipsychotic drugs, or SGAs are effective antipsychotics in these diseases, often in combination with antidepressants and mood stabilizers. Data on the possible effect of antipsychotics on neuro-cognition are rare and conflicting. The main objective of our study was to assess t...
متن کاملAsenapine: a synthesis of efficacy data in bipolar mania and schizophrenia.
INTRODUCTION This article briefly reviews the efficacy, as well as safety and tolerability, data pertaining to asenapine in bipolar mania and schizophrenia. Postulated mechanism of action is also reviewed. METHODS A PubMed search was conducted using the search term asenapine. All displayed articles were reviewed; we selected for review studies that were part of the regulatory registration pac...
متن کاملA Review of Asenapine in the Treatment of Bipolar Disorder
Bipolar disorder places a significant burden on the affected individuals, their family, healthcare systems and the overall economy. More treatment options are needed, especially those with better efficacy and tolerability. Asenapine is a second-generation antipsychotic approved in Europe (brand name Sycrest®) for the treatment of moderate-to-severe manic episodes associated with bipolar I disor...
متن کاملAsenapine for long-term treatment of bipolar disorder: a double-blind 40-week extension study.
BACKGROUND Asenapine is approved in the United States for acute treatment of manic or mixed episodes of bipolar I disorder with or without psychotic features. We report the results of long-term treatment with asenapine in patients with bipolar I disorder. METHODS Patients completing either of two 3-week efficacy trials and a subsequent 9-week double-blind extension were eligible for this 40-w...
متن کاملEffects of asenapine on agitation and hostility in adults with acute manic or mixed episodes associated with bipolar I disorder
Background Bipolar disorder is associated with an increased risk of aggression. However, effective management of hostility and/or agitation symptoms may prevent patients from becoming violent. This analysis investigated the efficacy of the antipsychotic asenapine on hostility and agitation in patients with bipolar I disorder. Methods Data were pooled from three randomized, double-blind, place...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2016